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Targeting ferritin or its regulators (e.g., NCOA4, ferroptosis suppressor protein 1[FSP1], Glutathione Peroxidase 4 [GPX4]) may sensitize tumors to iron-induced cell death

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While minor rolling is fine, aggressive shaking should be avoided

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This means that approximately 98% of small molecules and nearly all large therapeutic molecules, such as monoclonal antibodies, antisense oligonucleotides, or viral vectors, cannot pass through this barrier