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Metabolic flexibility or adaptation by cancer cells, as well as reduced antitumor immunity, may be unwanted consequences of inhibiting glutamine metabolism

Efficacy of upadacitinib in a randomized trial of patients with active ulcerative colitis

[DOI] [PubMed] [Google Scholar] Cai Z

Neurology 2020;94:e2189-202

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To investigate what underlines changes in Ca 2+ transients, we assessed levels and phosphorylation state of three major proteins that control the time constant and amplitude of Ca 2+ transient: Na + Ca 2+ exchanger (NCX1), sarco-endoplasmic reticulum Ca 2+ -ATPase (SERCa2), and phospholamban (PLN) (Figure 5C)