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Lancet Glob Health, 2018

Figure 9, and further details of the advantages and disadvantages of each method are listed in Supplementary Table 1

DCI arises not only from large-vessel vasospasm, but also from other complex pathophysiological processes, including thrombo-inflammation, neuro-inflammation, microcirculatory dysfunction, and glycocalyx disruption

DTI is a magnetic resonance imaging (MRI) technique that differentiates the degree and direction of water diffusion within an allotted space (Pierpaoli and Basser, 1996)

The Phase 2b trial (PMID: 23714218) failed to demonstrate significant weight loss compared to placebo over 12 weeks, despite adequate sample size and dosing