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According to the 2021 World Health Organization classification, gliomas are categorized into four grades (14) ( Table 1 )

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healthy individuals Research on ME/CFS patients compared to healthy controls has identified changes in intestinal microbiota, although no specific microbial signature has been consistently found (see Table 1) [12, 21,22,23,24,25,26,27,28,29,30,31]

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We followed the Preferred Reporting Items for Systematic Evaluations and Meta-Analyses (PRISMA) statement and the Cochrane Collaboration ( recommendations on reporting preferences

Interestingly, allopurinol, which is a structural isomer of Hx and is an inhibitor of the Xan oxidase, can improve SZ symptoms either when given alone or as add-on medication to haloperidol (Lara et al., 2001)