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This medicine is mainly used to treat Vitamin B12 deficiency in people with anemia and peripheral neuropathy (nerve pain in hands and feet)

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Bottom line: No receptor desensitization issue

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A broader methodological review reports that SUMO proteases maintain high cleavage fidelity across diverse conditions, temperature (437 C), pH (5.510.5), detergents, 2 M urea, tolerate various fusion partners, and rarely show off-target cleavagethough they cannot cleave proteins containing N-terminal proline immediately following the SUMO fusion [72,145]

Common Dosing Mistakes Even with a clear peptide dosage reference, common peptide mistakes happen