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This activation promotes localized inflammatory and fibrotic responses in the kidney by enhancing inflammatory factors MCP-1 and fibrotic markers such as collagen I and III [74]

A region in the brain called the hypothalamus regulates body temperature

These represent different approaches to metabolic optimization

It also modifies histones, thereby disrupting chromatin structure and generating genotoxic histoneDNA crosslinks [116]

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Notably, the results demonstrated that UA exerts its effects by downregulating microtubule-associated proteins 1A/1B light chain 3B and Lysosomal-associated membrane protein 1 expression, without significantly altering PINK1 and Parkin protein levels (36)