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Figure 2 4.1 High expression of all three key SSP enzymes: PHGDH, PSAT1 and PSPH 4.1.1 Non-small cell lung cancer In non-small cell lung cancer (NSCLC), the expression of PHGDH, the rate-limiting enzyme of the SSP, is significantly higher in tumor tissues than in adjacent normal tissues, and is positively correlated with TNM stage

Calculations of key parameters of the mitochondrial function were performed, consisting of basal respiration (BR, OCR initial OCR rot/AA ), ATP production (ATP, OCR initial - OCR oligo ), proton leak (PL, OCR oligo OCR rot/AA ), maximal respiration (MR, OCR FCCP OCR rot/AA ), spare respiratory capacity (SRC, OCR FCCP - OCR initial ), spare respiratory capacity [%] (SRCP, MR/BR*100), non-mitochondrial respiration rate (NMRR, OCR rot/AA ), and coupling efficiency [%] (CE, ATP/BR*100)

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Vitamin E is a component of the total ROO radical trapping antioxidant system [135]

Karas L, Asif M, Chun V, Khan FA

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