interaction of haloacetonitriles with glutathione and glutathione-s-transferase Induce Structure-Related Cellular Toxicity Through Distinct Proteome Thiol Reaction Mechanisms The glutathione S-transferase genes in

Our findings may inform novel therapeutic strategies for chronic inflammatory disorders, bridging traditional knowledge with contemporary mechanistic understanding

These cytokines not only amplify local inflammation but also further disrupt the System Xc GSHGPX4 axis and upregulate ACSL4 in neighboring tubular cells, creating a ferroptosis-inflammatory cascade that expands tubular injury

P.TrottaF.KushwahV.DevasariN.SinghC.SureshS.et al (2016)

(4) Utilizing the photothermal properties of NPTAs to improve BBB permeability

These studies suggest that antioxidant-based strategies may serve as adjunctive therapies in DR, particularly when integrated with broader metabolic control

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