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In general, the diagnosis is clinical and no laboratory tests or biopsies are required

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Even though methylation is the most examined chemical alteration till date, other less abundant forms of modifications, such as 5-hydroxymethlcytosine ( 5-hmC ), 5-formylcytosine ( 5-fC ), and 5-carboxycytosine ( 5-caC ) have now been described in specific contexts

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(Also in active treatment phase the levels are always going to be high, but going off it for four months to prove a point is not something I will do for anyone) The sweet spot for me is every two weeks with hydroxocobalamin

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Here are realistic timelines based on the clinical literature and practitioner experience: Realistic expectations matter

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