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Data For the present study, publicly available RNA-seq data from The Cancer Genome Atlas programme (TCGA patient data (GEO: GSE62944) [23], and the Cancer Cell Line Encyclopaedia (CCLE)) were combined with IN-HOUSE generated RNAseq data according to Table 1 and Supplementary File 1

Following injection (~20 larvae per condition), larvae were rinsed with E3 without methylene blue (E3-MB) to remove Tricaine and larvae were transferred to 35-mm Petri dishes

The neurotransmitter of the CholNS is acetylcholine (ACh)

[Google Scholar] 41.Weber F

These central nervous system effects contribute to appetite suppression (which is therapeutically beneficial) but can also produce nausea as a side effect

Cell Metab 30(4):675688