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Interestingly, some evidence supports the hypothesis that STK11/LKB1 co-mutation in KRAS mutated NSCLC could represent a negative predictive factor for immunotherapy (144)

Ondo WG, Tintner R, Voung KD, Lai D, Ringholz G (2005)

PANORAMA and a small study from Japan that examined the efficacy and tolerability of combination therapy with inhaled NAC and pirfenidone versus pirfenidone alone had findings that suggested more rapid disease progression in the group that received combination therapy [24]

635 The depressed mice induced by intermittent alcohol consumption showed significant iron deposition, increased TFRC expression, and decreased GPX4 expression in the hippocampus and prefrontal cortex

Clin Immunol 213:108352

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications