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Although restricted to animal studies, the KD is related to several pathways in metabolic syndrome and cancer, including increased 5 adenosine monophosphate-activated protein kinase (AMPK) activity, inhibition of the mTOR/AKT pathway, 134 lowering the serum ratio of insulin-like growth factor/IGF-binding protein 3 135 and increasing peroxisome proliferator-activated receptor- coactivator-1 expression (a master mitochondrial metabolic regulator that can increase mitochondrial biogenesis)

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Zhang Q, Gao Y, Zhang J, Li Y, Chen J, Huang R, Ma G, Wang L, Zhang Y, Nie K, Wang L (2020) L-Asparaginase exerts neuroprotective effects in an SH-SY5Y-A53T model of Parkinsons disease by regulating glutamine metabolism

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