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doi: 10.1186/1758-5996-6-80

Nat Rev Neurol 2009;5:610-20

These challenges underscore the necessity of integrating disease-specific modeling with pharmacological optimization and targeted delivery strategies, thereby transforming experimental ferroptosis models into translational platforms for musculoskeletal therapy development (Table II)

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292 In HD, the GABAergic neurons in the striatum and cortex are the most affected, contributing to clinical hallmarks such as chorea, cognitive impairment and nonmotor symptoms