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The principal function attributed to ICP34.5 involves enhancing viral propagation across peripheral tissues alongside central nervous systems, contributing significantly toward HSV, and inducing neurovirulence via various mechanisms including protein phosphatase I (PPI) dephosphorylating eIF2, thus preventing shutoff from host protein synthesis while enabling continuous production (11, 30, 31)

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doi: 10.1126/scitranslmed.aba0624 [DOI] [PubMed] [Google Scholar] 203