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The immune checkpoints CTLA-4 and PD-1, which are highly expressed in Treg cells, suppress glycolysis [145]

Intriguingly, the notably changed signaling pathways included metabolic pathways, fatty acid metabolism, fatty acid degradation, fatty acid elongation, biosynthesis of unsaturated fatty acids, oxidative phosphorylation (Figure 3A)

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The curvature of the intervertebral disc was examined with a bending fixture, and the relationship between the force of the curvature and the degree of motion of the intervertebral disc was measured

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