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In addition to predictable biomarkers in the VEGF family, patients in a ramucirumab plus FOLFIRI arm who underwent genomic analysis were all microsatellite stable and programmed death ligand 1 (PD -L1) may be a potential positive prognostic marker (69)

The rat appears to be a better model than the rabbit for studying human CYP2E1 expression and its role in metabolism of xenobiotics (Wrighton and Stevens 1992