Various topical, oral, and injection-based cosmetic skin-lightening agents with different mechanisms of action are used widely across Asia, including hydroquinone, azelaic acid, kojic acid, mulberry, alpha-arbutin, beta-arbutin, glutathione, licorice root, papaya, vitamin A (e.g., retinol), vitamin B (i.e., niacinamide), and vitamin C.1,2 One of the widely used systemic agents is glutathione, which is a thiol compound and a regulator of the melanogenic pathway in humans.3 Glutathione is an antioxidant found in the human body, contributing to drug and xenobiotic detoxification.3,4 It is known to be antimelanogenic, thereby associated with melanin production.5,6 It also inhibits tyrosinase activity and melanosome transfer from melanocytes to keratinocytes.48 Overall, it is suggested that glutathione might promote pheomelanin synthesis, inhibit intracellular melanogenic enzymes, and exhibit antioxidant and anti-aging effects.3 As demonstrated in in-vitro experiments, glutathione is associated with melanogenesis
Staying within Wells as independent brokers brings the convenience of familiar systems and avoids the hassles of having to repaper client accounts at a time when the team is meeting the challenges of running its own business, Schreiber said
Groups vulnerable to these deficiencies include individuals dealing with obesity, impaired nutrient absorption, renal issues, proton pump inhibitor (PPI) users, elderly individuals with elevated Clinical Frailty Scores, women, taller individuals, and post-bariatric surgery patients, especially those lacking postoperative care [3, 43,44,45]
Potential impurities in drug substances: compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides
The Importance of Purity If you and your doctor decide that glutathione is right for you, the quality of the supplement becomes the most important factor
Limit activities that could raise blood pressure (like exercise) Any activities that could raise blood pressure are best avoided for up to 48 hours following treatment
