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Artesunate inhibited the Notch signaling pathway, decreased Jagged1, NICD, and Hes-1 protein expression, reduced TGF-induced -smooth muscle actin (-SMA) and collagen content in fibroblasts, and inhibited the differentiation of fibroblasts into myofibroblasts (Liu et al., 2017)

The complexity and diversity of HCC can be attributed to the distinct genetic and molecular profiles present in the disease, ranging from early to advanced stages

Sodium 2-mercaptoethane sulfonate (Mesna) has traditionally been employed in clinical practice to counter cyclophosphamide-induced cystitis in humans

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Their role in neuroprotection is primarily attributed to their ability to mitigate oxidative stress, reduce neuroinflammation, modulate neurotransmitter activity, and enhance neurogenesis (Butterfield and Halliwell 2019)

Conclusion: There is a positive association between the use of antihypertensive medications including ACEIs/ARBs and CCBs, and the risk for HCC development in MASLD patients with cirrhosis