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Here, we summarized the possible positive effects of KD in reducing carbohydrate intake, ketosis status, neuroprotection, protecting glial cells, reducing inflammation, and regulating gut microbiota, against the negative effects caused by SUD (Figure 1)

Metabolic responses of Chinese perch ( Siniperca chuatsi ) to different levels of dietary carbohydrate

These compounds have been found to block oxidative damage in isolated mitochondria and cells more effectively than untargeted antioxidant analogs due to their concentration within mitochondria

Qiao et al., 2015

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Gd + / Gd females will have some degree of G6PD deficiency, but for clarity, we will always specify heterozygotes