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p62 was found to bind to the NRF2-binding site on KEAP1, thereby competing with NRF2 for KEAP1 binding [84]

Since the replacement of Gly with basic d-Arg in position 6 caused the local anaphylactoid reaction, new analogs with neutral d-ureidoalkyl amino acids, such as d-citruline at position 6were synthesized by our group 20