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n= 359 control), the pooled estimate favored ALC (SMD 1.20, 95% CI 2.12 to 0.29

MVD-affected dogs in heart failure have been shown to have significantly higher circulating levels of TMAO in their blood serum compared to healthy dogs and to dogs with pre-CHF MVD

10.1002/2211-5463.12635 37 HadiA.PourmasoumiM.KafeshaniM.KarimianJ.MaracyM

48 Parkinsons disease Aside from the aggregation of misfolded -synuclein in the intracellular Lewy bodies, a major neuropathological hallmark of PD is the loss of dopaminergic neurons within the SN

While these interactions do not establish direct causality, they provide integrative evidence linking metabolomic alterations to gene networks previously implicated in neurodevelopmental and metabolic regulation

In the aforementioned studies, the free radical scavenging and antioxidant properties of LC and its derivatives are demonstrated by: (a) restoration of the endogenous AO enzymes (SOD, CAT, GSH-Px, GR and GST) and non-enzymatic antioxidants (vitamins E and C) in the liver and other tissues of stressed animals