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doi: 10.1093/ageing/26.5.353 17

[Abstract]2025 Apr 22;16(1):3777

Liver-expressed antimicrobial peptide 2 (LEAP-2), the endogenous noncompetitive allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a), was recently identified as a key endocrine factor regulating systemic energy metabolism

As a consequence, the recommended approach could be useful as a detection method when used in combination with the biomarkers of the mycotoxin metabolism excreted into the urine or blood

In fact, the possibility of using glutathione for therapeutic purposes other than oxidative stress and further exploring the mechanisms by which it exerts its effects will also be helpful

DISCUSSION By combining previous models and making a few parameter changes, we have created a new model of glutathione metabolism that we have used to investigate sexual dimorphism in the glutathione pathway in the liver