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doi: 10.1126/sciadv.1400121 226 NaculLde BarrosBKingdonCCCliffJMClarkTGMudieKet al

104,105 ZnT5, on the other hand, possesses an unusually long N-terminal region with nine putative TM domains

Inhibition of PHGDH effectively reduces glycine availability and has been shown to alleviate fibrosis in experimental models [18]

Indeed, while no agent is yet supported by a definitive, placebo-controlled study, increasing evidence supports the potential utility of riluzole, memantine, N-acetylcysteine, D-cycloserine, and other glutamate-modulating agents in the treatment of this disorder