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Disclosures: Catherine Chang: Nothing to Disclose, Zhe Yang: Nothing to Disclose, Anjali Byale: Nothing to Disclose, Hansol Olivia Lee: Nothing to Disclose, Renwei Wang: Nothing to Disclose, Hung Luu: Nothing to Disclose, Jian-Min Yuan: Nothing to Disclose, Jaideep Behari: Pfizer: Grant/Research Support, Endra Life Sciences: Grant/Research Support, AstraZeneca: Grant/Research Support, Gilead: Grant/Research Support, Pfizer: Institutional research contract, Intercept: Institutional research contract, Madrigal: Institutional research contract, Inventiva: Institutional research contract, Rhythm: Institutional research contract, Galectin: Institutional research contract 2591 EFFECTS OF THE VERY LOW ENERGY DIET COMPARED TO A MEDITERRANEAN DIET ON HEPATIC AND METABOLIC OUTCOMES IN METABOLIC ASSOCIATED STEATOTIC LIVER DISEASE: A RANDOMISED CONTROL TRIAL Ann Farrell 1 Tonya Paris 2 Evelyn Parr 3 Elena George 2 Jessica Howell 1 Catherine Croagh 1 Tom Sutherland 1 Mark Page 1 Penelope McKelvie 1 Alexander Thompson 1 Marno Ryan 4 , 1 St Vincent's Hospital Melbourne, 2 Deakin University, Geelong, Victoria, Australia, 3 Australian Catholic University, Melbourne, Australia, 4 St

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10.1248/bpb.b17-00882 103 YinJ.ZhangF.CaoJ.ChenZ.XiongW

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Considerable heterogeneity exists across studies with respect to microbiome sequencing technologies, bioinformatic analysis pipelines, and population characteristics, which may contribute to inconsistencies in reported microbial signatures