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PMID: 14 WangRMurrayCSFowlerSJSimpsonADurringtonHJ

Mol Ther 16(6):10561064 Alam M, Yadav RK, Minj E, Tiwari A, Mehan S (2020) Exploring molecular approaches in amyotrophic lateral sclerosis: drug targets from clinical and pre-clinical findings

123 proposed that BI-4394 effectively blocked enzymatic activity of MMP13 to reduce levels of collagen degradation markers, specifically C2C fragments

Its putative trafficking to mitochondria has emerged as an important player as shown in a cohort of patients with established MASH, which exhibited increased free cholesterol content and high expression of the steroidogenic acute regulatory protein (STARD1) compared to patients with simple steatosis [87]