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Prescription Drugs Influence Microbiome: Unfortunately, many prescription medications used to manage lupus symptoms include immunosuppressive drugs which can increase the microbial imbalance in the gut

Am J Clin Nutr 1980;33:2151-6

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TLR4 signaling promotes the production of reactive oxygen species (ROS) via NADPH oxidase (NOX) enzymes and mitochondrial dysfunction, and the resulting oxidative stress causes further cellular damage, releasing more DAMPs that re-activate TLR4