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In: Greenspan's Basic & Clinical Endocrinology

From the view of the cytokine profile of IgG4-RD includes Th2 cytokines (IL-4, IL-5, and IL-13) and regulatory cytokines (IL-10 and tumor growth actor [TGF]-), the Th2 immune response play a key role in the pathophysiology of type1 AIP including IgG4-RD [76,77,78,79]

Andreeff M , Dembinski J, Studeny M, Ling X, Cabreira-Hansen M, Zompetta C, McQueen T, Fueyo J, Champlin RE, Marini FC

Bidirectional regulation of NF-B by reactive oxygen species: a role of unfolded protein response

The antioxidant and anti-inflammatory properties of thiamine help reduce fibrosis

For example, manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant enzyme, can undergo nitration of its tyrosine residues, leading to enzyme inactivation and contributing to oxidative stress and related diseases