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(6) Neuropharmacological Potential Yet to Be Explored: Although some literature suggests limited pharmacological properties of CX in the nervous system, the research is still in its preliminary stages

In the NOD mouse, a spontaneous immune-mediated diabetes model, treatment with GABA was preventative

Research into the effects of dietary supplements, such as vitamin B12, on tinnitus is limited

Acknowledgements We thank Hongxiang Lou, Yuemao Shen, and Shuangjiang Liu (Shandong University) for their support, the staff at Shanghai Synchrotron Radiation Facility beamline 19U and 17U for assistance with data collection, Xinwei Sun, Minzhi Jiang, Chengjia Zhang, Nannan Dong (State Key Laboratory of Microbial Technology, Shandong University) for assistance in experiments under anaerobic condition, Zhifeng Li, Jingyao Qu, Guannan Lin and Xiangmei Ren from the Core Facilities for Life and Environmental Sciences, State Key Laboratory of Microbial Technology, Shandong University for the assistance in LC-MS, DLS, and plate reader analysis

10.3389/fimmu.2021.752856 Front Immunol