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EURL ECVAM strategy to avoid and reduce animal use in genotoxicity testing Based on an analysis of regulatory requirements for this endpoint within different pieces of EU legislation, EURL ECVAM has proposed a pragmatic approach to improve the traditional genotoxicity testing paradigm that offers solutions in both the short- and medium-term and that draws on the considerable experience of 40 years of regulatory toxicology testing in this area (EURL ECVAM strategy to avoid and reduce animal use in genotoxicity testing, released in December 2013)