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Description

Immune Modulation

doi: 10.22201/facmed.20075057e.2020

Cyclophosphamide (Cy) is an alkylating agent with antineoplastic and immunosuppressive activity, whose bioactivation requires the activity of polymorphic enzymes in the liver to produce phosphoramide mustard, which is a DNA alkylating agent

Asia-Pacific Journal of Clinical Oncology

Subsequent isolation of splenocytes from C57BL/6 mice and incubation for 72 h in the presence of an anti-CD3 antibody with or without sulforaphane revealed a significant reduction in the differentiation of splenocytes into plasma B cells and germinal centre B cells, as well as a reduction in the production of proinflammatory factors

Gill, RR, Nowak, AK, Giroux, D, Eisele, M, Rosenthal, A, Kindler, HL, Wolf, A, Ripley, RT, Bill, A, Rice, DC , Opitz, I, Rimner, A, De Perrot, M, Pass, HI, Rusch, V