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Table 1 summarizes the various studies carried out to evaluate the effects of polyphenol in reversing MDR in cancer cell lines

& Liang, K

Colloids Surf B: Biointerfaces 115:125131 Tsao J-Y, Wu C-P, Tsai H-H, Peng K-C, Lin P-Y, Shan-Yu S, Chen L-D, Tsai F-J, Tsai Y (2012) Effect of hydroxypropyl--cyclodextrin complexation on the aqueous solubility, structure, thermal stability, antioxidant activity, and tyrosinase inhibition of paeonol

These actions may be associated with the suppression of the signal transducer and activator of transcription 3/Notch signaling axis, downregulation of the anti-apoptotic protein B-cell lymphoma-2 (Bcl-2), and upregulation of P53 expression

Glutathione can be taken orally, topically, or intravenously

This supplement is free of wheat, soy, dairy, and eggs, with no added sweeteners or artificial coloring