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One study found increased oxygen uptake in muscle tissue even when availability was lower

Clinical studies highlight that taking 500 mg of quercetin daily for 4 weeks lowered plasma uric acid levels from 5.46 to 5.04 mg/dL in humans [8]

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doi: 10.1111/febs.16059 52

The azotemia progressed to IRIS AKI Grade 3 by Day 91 and became severe during the terminal stage of the disease (Day 112), with a BUN of 83 mg/dL (reference range, 1636 mg/dL) and creatinine of 5.0 mg/dL (reference range, 0.82.4 mg/dL)