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Ethanol metabolism alters the cytosolic and mitochondrial redox states [NADH/NAD + ] and it may exacerbate mitochondrial ROS production by increasing the flow of electron down the respiratory chain

(iv) down-regulation of production of glutathione scavengers of cytotoxic reactive oxygen species (ROS) 149,150

10.1016/j.jff.2022.105186 71 ZhangC.HeX.ShengY.XuJ.YangC.ZhengS.et al (2020)

Both the cytosolic Grx1-roGFP2 and the plastidic TKTP-Grx1-roGFP2 lines exhibited a noticeable decrease in fluorescence intensity when excited at 488 nm following 24 h and 48 h AITC treatments