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Tintinallis Emergency Medicine: Just the Facts

Nonetheless, it is conceivable that exercise-induced changes in one or all of these antioxidant systems could contribute to the redox adaptation to exercise

Hormonal status: Perimenopausal and postmenopausal women may see a slower response due to estrogen-driven collagen decline

doi:10.1016/j.mrgentox.2006.05.006

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

Reactive oxygen species result in the formation of free radicals, highly reactive molecules which cause cellular and tissue damage in the form of oxidative stress