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Microglia can influence neuronal firing through activity-dependent release of pro-inflammatory mediators and neuromodulatory factors, including cytokines and neurotrophic signals that regulate synaptic strength and network excitability (Klapal et al., 2016)

IGF- 1 Insulin Growth Factor- 1 researchers from UCLA have identified cross-talk between insulin/IGF- 1 and GPCR signaling systems as a key to pancreatic cancer growth, and since Metformin has been shown to block this cross-talk, they propose Metformin as a promising candidate for pancreatic cancer prevention and treatment

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