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Unlike oral supplements, which have to go through the digestive system and can be affected by factors like stomach acid and digestive enzymes, injections deliver the vitamin directly into your bloodstream

Selenium deficiency induced the expression of the chondrocyte hypertrophy marker gene type X collagen (COLX) in articular cartilage 64

however, they can also lead to nutrient depletion

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Under the catalytic action of IDO1/2 and TDO, tryptophan is metabolized to kynurenine (Kyn)