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In addition to the co-delivery of therapeutic agents with siRNA or new-generation potent P-gp inhibitors mentioned above, co-delivery of therapeutic agents with natural alkaloids (such as tetrandrine, quercetin (QUE), kaempferol, and icaritin) may be a good strategy when facing the failure of first- and second-generation P-gp inhibitors (such as verapamil, cyclosporine A, and dexverapamil) ( 2.2 Inducing cell apoptosis in cancer therapy Apoptosis is programmed cell death that is initiated after damage to DNA and cell organelles, such as the mitochondria and endoplasmic reticulum ( In vivo TUNEL assays also showed that tumors in the CDDP/CUR-Lip group had the largest proportion of apoptotic tumor cells

15 The positive impacts of postbiotics on gastrointestinal health and immune system function are just beginning to be explored in clinical studies

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Lactobacillus casei ATCC 393 alleviates enterotoxigenic Escherichia coli K88-induced intestinal barrier dysfunction via TLRs/mast cells pathway