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This selective inhibition was demonstrated to have a significant effect on human tumor cells by inducing DNA damage in vitro and in vivo experiments, without significantly impacting normal cells

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Ascorbate and glutathione can individually participate in ROS detoxification operations, but their essential role results from their association in the context of the ascorbate-glutathione cycle (AGC), also called the Halliwell-Asada-Foyer cycle, after the scientists who identified it (see Focus on Hydroperoxide detoxification)