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Rights and permissions About this article Cite this article Abalenikhina, Y.V., Suchkova, O.N., Kostyukova, E.V

During parasite infection, macrophages primarily display an anti-inflammatory M2-like phenotype, as characterized by the expression of specific effector molecules, such as arginase-1 (Arg1), Ym1 and resistin-like molecules (RELM)

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Updated phase 3 titration pathway The phase 3 schedule uses the following escalation: Weeks 1-4: 2mg weekly Weeks 5-8: 4mg weekly Weeks 9-12: 8mg weekly Week 13+: Maintenance dose (4mg, 9mg, or 12mg depending on assignment) The introduction of a 9mg dose option is interesting

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