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Wang (2015) formulated the classification and criteria required for a molecule which may be called a gasotransmitter: (1) A small, gaseous molecule dissolved or not in the cytosol (biological milieu) (2) Permeability through the membranes, thus intracellular and intercellular movements do not rely on membrane receptors or transporters, (3) Endogenous production depending on specific substrate and enzyme, under metabolic control, the molecule should not be the product of metabolism only, (4) Well-defined specific functions at physiologically relevant concentrations, (5) Endogenously synthesised gas can be mimicked by its exogenously applied counterpart, (6) It is possible to describe its signal transduction pathway and specify cellular and molecular targets

Thats been a tremendous advance

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