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If accurate, that points to a signaling or regulatory effect rather than a direct hypnotic one

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The Journal of clinical and aesthetic dermatology, 3(10), 2628.

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Histone deacetylase (HDAC) inhibitors have been shown to upregulate PGRN transcription in cell culture systems, including iPSC-derived neurons [241,242,243] but failed to increase plasma and CSF PGRN levels in participants with GRN haploinsufficiency in a phase 2a clinical trial [244]