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In the current study, CPZ consumption elicited behavioral and motor anomalies as established by tail suspension test and inverted screen grip strength test in both CPZ-DE and CPZ-RE groups compared to normal controls

Sodium l-lactate and sodium d-lactate (Sigma Aldrich) were dissolved in Neurobasal medium (Thermo Fisher Scientific) and added before hypoxia at different concentrations (51020 mM of l-lactate and 10 mM of d-lactate)

Secondary antibodies used were horseradish peroxidase-linked anti-rabbit (CST, ##7074, 1:5000 dilution), horseradish peroxidase-linked anti-mouse (CST, #7076, 1:5000 dilution), DyLight-800 4 PEG-linked anti-rabbit (CST, #5151, 1:5000 dilution), and DyLight 680-linked anti-mouse (CST, #5470, 1:5000 dilution)

CD also acknowledges support by the Minna-James-Heineman Foundation through a Heineman Project Grant, administered by the Minerva Foundation