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S2 and S3)

F., Sharma, R

In those cases, appropriate hormone replacement will be lifelong, but the irAE does not typically require treatment discontinuation

M.HitchensT

Eligible participants were then invited to attend the sleep clinic for a comprehensive sleep assessment by a sleep physician or sleep psychologist who diagnosed Insomnia Disorder using DSM-5 1 , with participants having difficulty initiating or maintaining sleep or waking up too early for at least three nights per week and greater than three months, with adequate opportunity for sleep coupled with daytime impairment related to the sleep difficulty

So having two copies of C677T (or one copy of C677T and one copy of A1298C) really only increases the risks for certain problems