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The ethanolic extract of BM at the dose of 200 mg/kg showed a good hepatoprotective effect in nitrobenzene-induced liver damage in mice model by an increase in SOD, CAT and GPx enzymes and by normalizing the serum marker enzymes such as aspartate transaminase, alanine transaminase, and alkaline phosphatase

Along with this, cerebrovascular accident (CVA) is currently the second leading cause of death in the Western world, ranking after heart disease and before cancer[337], and experts predict that it is likely to be soon the most common cause of death worldwide[338]

In addition, CL-bromelain was reported for its suppression of ERK, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase (145)

Rains and C

This research has been conducted following the tenets of the Declaration of Helsinki and approved by the ethics committee of Medical Faculty

Similarly, nine of the seventeen residues (Q637 3.29 , H641 3.33 , H721 ex2 , S726 5.39 , F730 5.43 , W775 6.48 , F778 6.51 , L782 6.55 , and C801 7.39 ) mediate activation by cyclamate, while six (Q637 3.29 , H641 3.33 , W775 6.48 , F778 6.51 , L782 6.55 , and C801 7.39 ) influence receptor inhibition by lactisole as well as receptor activation by cyclamate [superscript refers to the nomenclature suggested for class C GPCRs by Pin et al