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Our cryo-EM map of holo-complex shows strong elongated density peaks between the IPT1 domain of c-MET II and N domain of HGF I that can be assigned to heparin, based on the size and shape of the density as well as the local chemical environment (Fig

Komolov KE, Benovic JL

Karuna Therapeutics Submits New Drug Application to U.S

Thomas et al ., 2024) Elp homologs were immobilized onto a CMD200 sensor chip (XanTec bioanalytics) via amine coupling, using concentrations of 10 g/mL in 10 mM sodium acetate (pH 5.0