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Furthermore, TSEL nanovesicles co-delivering BACE1 siRNA and a TREM2 plasmid effectively penetrated the BBB and accumulated at AD lesions in vivo in APP/PS1 mice (Jiang et al., 2024)

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The proposed Circular A16 supplemental guidance establishes a repeatable process for updating the list of nationally significant data themes and their responsible lead agencies designated in Circular A16, Appendix E

Lipidomic analysis revealed significant differences in most of the lipid classes we assessed

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