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Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases

6.2.3 LRRK2 and mitochondrialinflammatory cross-talk Elevated LRRK2 activity has been tied to mitochondrial DNA damage responses and inflammatory signaling, situating LRRK2 at the intersection of redox stress and innate immunity in PD-relevant systems (130)

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Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in parkinson's disease

Sirt2 inhibition reduces histone hypoacetylation in dopaminergic neurons and downregulates neuroinflammation via reducing iNOS and COX-2 expression (Harrison et al., 2018)