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L-carnitine tartrate decreases SARS-CoV-2 infection of Calu-3 cells by downregulating ACE2 receptor expression Immune responses, clinical presentations and severity of outcomes vary notably among patients infected by COVID-19, and include muscle weakness, fever and respiratory complications

The participants had emptied their bladders and bowels prior to the measurement

More specifically, the present invention relates to a process for preparing L-carnitine or acetyl L-carnitine hydrochloride, comprising sequentially synthesizing racemic 4-chloro-3-hydroxybutyronitrile of Formula 2 and racemic 4-chloro-3-hydroxy butyric acid alkyl ester of Formula 3 under specific reaction conditions, using racemic epichlorohydrin of Formula 1 as a starting material, preparing (R)-4-chloro-3-hydroxy butyric acid alkyl ester of Formula 4 from stereoselective hydrolysis of the racemic 4-chloro- 3 -hydroxy butyric acid alkyl ester in an aqueous solution using an enzyme, and preparing L-carnitine of Formula 6 or acetyl L-carnitine hydrochloride of Formula 7 from the (R)-4-chloro-3-hydroxy butyric acid alkyl ester

valproic acid A61K31/191Carboxylic acids, e.g

There have been a few studies on acetyl-L-carnitines use as a treatment