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Conversely, other metabolic products may serve as strong enzyme inhibitors

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Moreover, EMT can enhance the secretion of TGF- and inflammatory cytokines by damaged epithelial cells, which, respectively, promote the differentiation of fibroblasts into myofibroblasts and trigger immune inflammation, ultimately resulting in repair failure and tissue fibrosis (83, 84)

Human cytomegalovirus may promote tumour progression by upregulating arginase-2