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44 Moreover, the MC@PHDA hydrogel achieves physical targeting clearance of hepatocellular carcinoma by activating the photothermal effect of MoS 2 and the photodynamic action of Chlorella through spatiotemporally precise irradiation with 660 nm and 808 nm lasers, generating local hyperthermia and ROS

Therapeutic potential was first demonstrated in multiple myeloma models, where elesclomol synergized with proteasome inhibitors by activating the mitochondrial Cu 2+ -ROS axisrevising prior attributions of cytotoxicity solely to lipid peroxidation (Figure 7)

Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin-resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy